Compounds > 2-[[2-[2-(4-methoxyanilino)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]propanoic acid ethyl ester
Page last updated: 2024-08-01 03:51:36

2-[[2-[2-(4-methoxyanilino)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]propanoic acid ethyl ester

Description

2-[[2-[2-(4-methoxyanilino)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]propanoic acid ethyl ester : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID4131581
CHEMBL ID262079
CHEBI ID91559

Synonyms (18)

Synonym
isoquinolinone scaffold, 31
ethyl 2-[(2-{[(4-methoxyphenyl)carbamoyl]methyl}-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoate
bdbm28647
SR-03000000023-1
ml017
CHEMBL262079 ,
smr001398718
MLS002474583
ethyl 2-[2-[2-(4-methoxyanilino)-2-oxoethyl]-1-oxoisoquinolin-5-yl]oxypropanoate
bdbm50341557
ethyl 2-(2-(2-(4-methoxyphenylamino)-2-oxoethyl)-1-oxo-1,2-dihydroisoquinolin-5-yloxy)propanoate
F1808-0154
868224-58-2
ethyl 2-((2-(2-((4-methoxyphenyl)amino)-2-oxoethyl)-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy)propanoate
AKOS024610205
CHEBI:91559
2-[[2-[2-(4-methoxyanilino)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]propanoic acid ethyl ester
Q27163392

Drug Classes (1)

ClassDescription
isoquinolinesA class of organic heteropolycyclic compound consisting of isoquinoline and its substitution derivatives.

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Steroidogenic factor 1Homo sapiens (human)IC500.2000AID329653; AID593523

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Steroidogenic factor 1Homo sapiens (human)EC500.2000AID1798910

Bioassays (12)

Assay IDTitleYearJournalArticle
AID593523Inverse agonist activity at SF-12011Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
ISSN: 1520-4804		Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2).
AID593524Antiproliferative activity against SF-1 negative human SW13 cells2011Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
ISSN: 1520-4804		Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2).
AID329653Inhibition of GAL4-tagged NR5A1 by luciferase assay2008Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8
ISSN: 1464-3405		Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds.
AID329656Inhibition of GAL4-tagged RORalpha at 100 uM by luciferase assay2008Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8
ISSN: 1464-3405		Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds.
AID593525Inhibition of doxycycline induced proliferation in human NCI-H295RR cells2011Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
ISSN: 1520-4804		Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2).
AID329658Inhibition of HSV1 GAL4-tagged VP16 at 100 uM by luciferase assay2008Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8
ISSN: 1464-3405		Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1798910Transactivation Cell-Based Assay from Article 10.1016/j.bmcl.2008.03.027: \\Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds.\\2008Bioorganic & medicinal chemistry letters, Apr-15, Volume: 18, Issue:8
ISSN: 1464-3405		Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds.

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
pk 11195
0
aromatic amide;
isoquinolines;
monocarboxylic acid amide;
monochlorobenzenes		antineoplastic agent00low000000
5-aminoisoquinolinone
0
isoquinolines00low000000
debrisoquin
0
carboxamidine;
isoquinolines		adrenergic agent;
antihypertensive agent;
human metabolite;
sympatholytic agent		00low000000
ethaverine
0
isoquinolines00low000000
n-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide
0
isoquinolines;
sulfonamide		00low000000
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
0
bromobenzenes;
isoquinolines;
olefinic compound;
secondary amino compound;
sulfonamide		EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor00low000000
1-(5-isoquinolinesulfonyl)-2-methylpiperazine
0
isoquinolines;
N-sulfonylpiperazine		EC 2.7.11.13 (protein kinase C) inhibitor00low000000
1-(5-isoquinolinesulfonyl)piperazine
0
isoquinolines00low000000
ha 1004
0
isoquinolines00low000000
fasudil
0
isoquinolines;
N-sulfonyldiazepane		antihypertensive agent;
calcium channel blocker;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
geroprotector;
neuroprotective agent;
nootropic agent;
vasodilator agent		00low000000
hydrocotarnine
0
isoquinolines00low000000
nomifensine
0
isoquinolinesdopamine uptake inhibitor00low000000
6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one
0
isoquinolines00low000000
papaverine
0
benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent		00low000000
praziquantel
0
isoquinolines00low000000
scriptaid
0
isoquinolines00low000000
tilisolol
0
isoquinolines00low000000
cotarnine
0
isoquinolines00low000000
dimethisoquin
0
isoquinolines00low000000
1,2,3,4-tetrahydroisoquinoline
0
isoquinolines00low000000
isoquinoline
0
azaarene;
isoquinolines;
mancude organic heterobicyclic parent;
ortho-fused heteroarene		00low000000
cepharanthine
0
bisbenzylisoquinoline alkaloid;
isoquinolines		00low000000
bicuculline
0
benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines		agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin		00low000000
isocarbostyril
0
isoquinolines00low000000
salsolidine
0
isoquinolines00low000000
laudanosine
0
isoquinolines00low000000
1-methylisoquinoline
0
isoquinolines00low000000
heliamine
0
aromatic ether;
diether;
isoquinoline alkaloid;
isoquinolines		plant metabolite00low000000
1,2-dehydrosalsolinol
0
isoquinolines00low000000
dehydroemetine
0
aromatic ether;
isoquinolines;
pyridoisoquinoline		antileishmanial agent;
antimalarial;
antiprotozoal drug		00low000000
metocurine
0
isoquinolines00low000000
thalicarpine
0
bisbenzylisoquinoline alkaloid;
isoquinolines		00low000000
dimoxyline
0
isoquinolines00low000000
6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline
0
isoquinolines00low000000
coralyne
0
isoquinolines00low000000
(3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-isobenzofuran-1-one
0
isoquinolines00low000000
salsoline
0
isoquinolines00low000000
isosalsoline
0
isoquinolines00low000000
amonafide
0
isoquinolines00low000000
daurisoline
0
isoquinolines00low000000
magnocurarine
0
isoquinolines00low000000
quinapril
0
dicarboxylic acid monoester;
ethyl ester;
isoquinolines;
tertiary carboxamide		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
prodrug		00low000000
tretoquinol
0
isoquinolines00low000000
moxaverine
0
isoquinolines00low000000
tritoqualine
0
isoquinolines00low000000
tubulosine
0
beta-carbolines;
isoquinoline alkaloid;
isoquinolines;
phenols;
secondary amino compound;
tertiary amino compound		00low000000
hernandezine
0
bisbenzylisoquinoline alkaloid;
isoquinolines		00low000000
tetrandrine
0
bisbenzylisoquinoline alkaloid;
isoquinolines		00low000000
dauricine
0
aromatic ether;
bisbenzylisoquinoline alkaloid;
isoquinolines;
phenols;
tertiary amino compound		plant metabolite00low000000
cherylline
0
isoquinolines00low000000
gliquidone
0
isoquinolines00low000000
1-methyl-1,2,3,4-tetrahydroisoquinoline
0
isoquinolines00low000000
laudanosoline
0
isoquinolines00low000000
papaveraldine
0
isoquinolines00low000000
corydaline
0
isoquinoline alkaloid;
isoquinolines		00low000000
4-hydroxydebrisoquin
0
carboxamidine;
isoquinolines;
secondary alcohol		metabolite00low000000
quinaprilat
0
dicarboxylic acid;
isoquinolines;
tertiary carboxamide		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
vasodilator agent		00low000000
cycleanine
0
bisbenzylisoquinoline alkaloid;
isoquinolines		00low000000
dihydrotetrabenazine
0
isoquinolines00low000000
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
0
isoquinolines;
organochlorine compound		00low000000
1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
0
isoquinolines00low000000
cki 7
0
isoquinolines;
organochlorine compound;
primary amino compound;
sulfonamide		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor00low000000
pixantrone
0
isoquinolines00low000000
isodibut
0
isoquinolines00low000000
3,4-dihydro-5-methyl-1(2h)-isoquinolinone
0
isoquinolines00low000000
solifenacin
0
isoquinolines00low000000
liensinine
0
isoquinolines00low000000
trilobine
0
isoquinolines00low000000
corynoline
0
benzophenanthridine alkaloid;
cyclic acetal;
isoquinolines;
organic heterohexacyclic compound;
secondary alcohol		antineoplastic agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
hepatoprotective agent;
metabolite		00low000000
minalrestat
0
isoquinolines00low000000
hydrastine
0
isoquinolinesmetabolite00low000000
pronuciferine
0
aromatic ether;
cyclic ketone;
isoquinoline alkaloid;
isoquinolines;
organic heterotetracyclic compound		plant metabolite00low000000
5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine
0
isoquinolines00low000000
solifenacin succinate
0
isoquinolines00low000000
berbamine
0
bisbenzylisoquinoline alkaloid;
isoquinolines		00low000000
2-(2-oxolanylmethyl)benzo[de]isoquinoline-1,3-dione
0
isoquinolines00low000000
guatteguamerine
0
bisbenzylisoquinoline alkaloid;
isoquinolines		00low000000
korupensamine-b
0
isoquinolines;
naphthalenes		00low000000
obamegine
0
bisbenzylisoquinoline alkaloid;
isoquinolines		00low000000
hydrastine hydrochloride, (s-(r*,s*))-isomer
0
isoquinolines00low000000
narcotoline
0
isoquinolines00low000000
oxyacanthine
0
bisbenzylisoquinoline alkaloid;
isoquinolines;
macrocycle;
phenols;
tertiary amino compound		00low000000
floxacillin
0
isoquinolines00low000000
dioncophylline a
0
biaryl;
isoquinoline alkaloid;
isoquinolines;
methoxynaphthalene;
methylnaphthalenes;
naphthalenes		antifungal agent;
antimalarial;
metabolite;
molluscicide		00low000000
dioncophylline c
0
aromatic ether;
biaryl;
isoquinoline alkaloid;
isoquinolines;
methoxynaphthalene;
methylnaphthalenes;
naphthols		antimalarial;
antiplasmodial drug;
metabolite		00low000000
h 1152
0
isoquinolines;
N-sulfonyldiazepane		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor00low000000
9,10-dimethoxy-2,4,6,7-tetrahydro-[1,3]oxazino[4,3-a]isoquinoline-1-carbonitrile
0
isoquinolines00low000000
hydrastine, (r-(r*,s*))-isomer
0
isoquinolines00low000000
6,7-dimethoxy-N-(4-methylphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-2-carboxamide
0
isoquinolines00low000000
5-(3,4-dihydro-1H-isoquinolin-2-yl)-2-(2-furanyl)-4-oxazolecarbonitrile
0
isoquinolines00low000000
1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-phenyl-1-butanone
0
isoquinolines00low000000
methyl isoquinoline-3-carboxylate
0
isoquinolines00low000000
1-(3,4-dihydro-1H-isoquinolin-2-yl)-2-(2-fluorophenoxy)ethanone
0
isoquinolines00low000000
1-spiro[2,4-dihydroisoquinoline-3,1'-cyclohexane]thione
0
isoquinolines00low000000
N-(4-methoxyphenyl)-3,4-dihydro-1H-isoquinoline-2-carbothioamide
0
isoquinolines00low000000
N-(4-fluorophenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide
0
isoquinolines00low000000
3-amino-2-(4-methoxyphenyl)-7-nitro-1-oxo-4-isoquinolinecarbonitrile
0
isoquinolines00low000000
4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-(2,6-dimethylphenyl)benzamide
0
isoquinolines00low000000
LSM-16526
0
isoquinolines00low000000
drotaverin
0
isoquinolines00low000000
5,5-diethyl-1-[oxo(1-piperidinyl)methyl]-6H-pyrrolo[2,1-a]isoquinoline-2,3-dione
0
isoquinolines00low000000
N-(4-fluorophenyl)-2-(5-methoxy-1-oxo-2-isoquinolinyl)acetamide
0
isoquinolines00low000000
2-[[1-oxo-2-[2-oxo-2-(1-piperidinyl)ethyl]-5-isoquinolinyl]oxy]acetic acid ethyl ester
0
isoquinolines00low000000
2-[[2-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]acetic acid ethyl ester
0
isoquinolines00low000000
5-[[2-[(3-methylphenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxymethyl]-2-furancarboxylic acid methyl ester
0
isoquinolines00low000000
5-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethoxy]-2-[(3-methylphenyl)methyl]-3,4-dihydroisoquinolin-1-one
0
isoquinolines00low000000
4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-[4-(1-pyrrolidinylsulfonyl)phenyl]benzamide
0
isoquinolines00low000000
4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-[4-(1-piperidinylsulfonyl)phenyl]benzamide
0
isoquinolines00low000000
1-(5-isoquinolinyl)-3-(2-phenylethyl)thiourea
0
isoquinolines00low000000
1-(4-ethoxyphenyl)-3-(5-isoquinolinyl)thiourea
0
isoquinolines00low000000
4-[[5-(difluoromethylthio)-4-methyl-1,2,4-triazol-3-yl]methoxy]-5-methylisoquinoline
0
isoquinolines00low000000
2-[[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]thio]-3-ethyl-5,6-dimethyl-4-thieno[2,3-d]pyrimidinone
0
isoquinolines00low000000
N-[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-2-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(2-methoxyethyl)acetamide
0
isoquinolines00low000000
2-(Methylamino)-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione
0
isoquinolines00low000000
3-[3-(1,3-dioxo-2-benzo[de]isoquinolinyl)propylthio]propanoic acid
0
isoquinolines00low000000
4-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-(1,1-dioxo-3-thiolanyl)butanamide
0
isoquinolines00low000000
2-[4-(3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyl]benzo[de]isoquinoline-1,3-dione
0
isoquinolines00low000000
4-bromobenzenesulfonic acid (1,3-dioxo-2-benzo[de]isoquinolinyl) ester
0
isoquinolines00low000000
2-(3-hydroxyphenyl)-6-(1-piperidinyl)benzo[de]isoquinoline-1,3-dione
0
isoquinolines00low000000
2-[3-(1H-1,2,4-triazol-5-ylthio)propyl]benzo[de]isoquinoline-1,3-dione
0
isoquinolines00low000000
2-[2-[4-[2-hydroxy-3-(2-methylphenoxy)propyl]-1-piperazinyl]ethyl]benzo[de]isoquinoline-1,3-dione
0
isoquinolines00low000000
2-benzoyl-N-(6-methoxy-3-pyridinyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide
0
isoquinolines00low000000
mcn 5652
0
isoquinolines00low000000
3-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-N-(6-methyl-2-pyridinyl)-1-oxo-3,4-dihydroisoquinoline-4-carboxamide
0
isoquinolines00low000000
4-[(4-cyclohexyl-1-piperazinyl)-oxomethyl]-2-ethyl-6,7-dimethoxy-1-isoquinolinone
0
isoquinolines00low000000
1-[[1-(2-methoxyanilino)-4-isoquinolinyl]-oxomethyl]-4-piperidinecarboxamide
0
isoquinolines00low000000
3,4-dihydro-1H-isoquinolin-2-yl-(1-ethylsulfonyl-4-piperidinyl)methanone
0
isoquinolines00low000000
1-cyclopentyl-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-5-oxo-3-pyrrolidinecarboxamide
0
isoquinolines00low000000
3-(3,4-dimethoxyphenyl)-2-methyl-N-[2-(4-morpholinyl)ethyl]-1-oxo-3,4-dihydroisoquinoline-4-carboxamide
0
isoquinolines00low000000
1-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-3-(4-ethylphenyl)urea
0
isoquinolines00low000000
6,7-dimethoxy-N-[(5-methyl-2-furanyl)methyl]-2-(2-methylpropyl)-1-oxo-4-isoquinolinecarboxamide
0
isoquinolines00low000000
4-[[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholine
0
isoquinolines00low000000
5-[3,4-dihydro-1H-isoquinolin-2-yl(phenyl)methyl]-6-thiazolo[3,2-b][1,2,4]triazolol
0
isoquinolines00low000000
4-chloro-N-[1-(3,4-dihydro-1H-isoquinolin-2-yl)-2-methylpropan-2-yl]benzenesulfonamide
0
isoquinolines00low000000
5-[2-[3-(4-fluorophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-oxoethoxy]-2-(phenylmethyl)-3,4-dihydroisoquinolin-1-one
0
isoquinolines00low000000
2-[[2-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]propanoic acid ethyl ester
0
isoquinolines00low000000
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(4-fluorophenyl)-2-(2-methoxyethyl)-1-oxo-3,4-dihydroisoquinoline-4-carboxamide
0
isoquinolines00low000000
2-(4-chlorophenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
0
isoquinolines00low000000
4-phenyl-1,2,3,4-tetrahydroisoquinoline
0
isoquinolines00low000000
6,7-dimethoxy-N-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamide
0
isoquinolines00low000000
8-nitro-5-[3-(trifluoromethyl)-1-piperidinyl]isoquinoline
0
isoquinolines00low000000
2-(3-methyl-1-oxo-2-isoquinolinyl)-N-(3,4,5-trimethoxyphenyl)acetamide
0
isoquinolines00low000000
8-hydroxymanzamine a
0
alkaloid;
beta-carbolines;
isoquinolines		anti-HSV-2 agent;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
metabolite		00low000000
isoliensinine
0
isoquinolines00low000000
mivacurium
0
isoquinolines00low000000
bw b1090u
0
isoquinolines00low000000
3,4-dihydro-1H-isoquinolin-2-yl-(4-ethyl-5-thieno[3,2-b]pyrrolyl)methanone
0
isoquinolines00low000000
papaveroline
0
isoquinolines00low000000
norbinaltorphimine
0
isoquinolines00low000000
naltrindole
0
isoquinolines00low000000
manzamine a
0
alkaloid;
beta-carbolines;
isoquinolines		animal metabolite;
anti-HSV-1 agent;
antimalarial;
antineoplastic agent;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
marine metabolite		00low000000
2-(2-phenylethyl)benzo[de]isoquinoline-1,3-dione
0
isoquinolines00low000000
ripasudil
0
isoquinolines00low000000
ancistroealaine a
0
aromatic ether;
biaryl;
isoquinoline alkaloid;
isoquinolines;
methoxynaphthalene;
methylnaphthalenes		antileishmanial agent;
antiplasmodial drug;
metabolite;
trypanocidal drug		00low000000
SIS3 free base
0
aromatic ether;
enamide;
isoquinolines;
monocarboxylic acid amide;
pyrrolopyridine;
tertiary carboxamide		Smad3 inhibitor00low000000
fg-4592
0
aromatic ether;
isoquinolines;
N-acylglycine		EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor		00low000000
sar 1118
0
1-benzofurans;
isoquinolines;
L-phenylalanine derivative;
N-acyl-L-alpha-amino acid;
sulfone		anti-inflammatory drug;
lymphocyte function-associated antigen-1 antagonist		00low000000
4-(4-chlorophenyl)sulfonyl-5-(3,4-dihydro-1H-isoquinolin-2-yl)-2-ethylsulfonylthiazole
0
isoquinolines00low000000
bebeerine
0
bisbenzylisoquinoline alkaloid;
isoquinolines		00low000000
(1S)-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-2-oxido-3,4-dihydro-1H-isoquinolin-2-ium-7-ol
0
isoquinolines;
tertiary amine oxide		00low000000
dihydrotetrabenazine, (2alpha,3beta,11bbeta)-isomer
0
isoquinolines00low000000
jorunnamycin a
0
isoquinolines00low000000
1-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-3-(4-nitrophenyl)urea
0
isoquinolines00low000000
2-(1,3-benzodioxol-5-ylmethyl)-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline
0
isoquinolines00low000000
N-(3-nitrophenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide
0
isoquinolines00low000000
2-(5-butoxy-1-oxo-2-isoquinolinyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide
0
isoquinolines00low000000
almorexant
0
isoquinolines00low000000
ipi-145
0
isoquinolines00low000000
nbi 31772
0
aromatic ketone;
benzenediols;
hydroxy monocarboxylic acid;
isoquinolines;
tetrol		insulin-like growth factor-binding protein inhibitor00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
ac 45594
1
aromatic ether2011201113.0high000010
2-[[2-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]propanoic acid ethyl ester
1
isoquinolines2008200816.0high000100
2-(5-butoxy-1-oxo-2-isoquinolinyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide
1
isoquinolines2008200816.0high000100
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Inflammation0
1
2010201014.0high000100
Innate Inflammatory Response0
1
2010201014.0high000100